Drug interactions
Papaverine + Primidone
Severity: Minor
Papaverine and Primidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Primidone, which is metabolized to phenobarbital, causes sedation. Papaverine may add a small sedative effect, so drowsiness could be somewhat more noticeable, particularly early in therapy.
What this interaction means in plain words
Papaverine and Primidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Papaverine belongs to Cardiovascular; Primidone belongs to Central Nervous System.
Why it happens
Possible additive CNS depression; papaverine's effect is weak and not well established.
What to do
Counsel about drowsiness and avoidance of hazardous activities until the response is known. No dose change is usually needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Papaverine
- Givinostat + Papaverine Major
- Bretylium + Papaverine Moderate
- Calcium / magnesium / potassium / sodium oxybates + Papaverine Moderate
- Carbidopa-entacapone-levodopa + Papaverine Moderate
- Carbidopa-levodopa + Papaverine Moderate
- Carbidopa + Papaverine Moderate
Other interactions of Primidone
- Lorlatinib + Primidone Contraindicated
- Lurasidone + Primidone Contraindicated
- Primidone + Ranolazine Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Voriconazole Contraindicated
- Abiraterone + Primidone Major
Frequently asked questions
Can I take Papaverine with Primidone?
MediHelp rates the interaction as minor. Papaverine and Primidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Primidone, which is metabolized to phenobarbital, causes sedation. Papaverine may add a small sedative effect, so drowsiness could be somewhat more noticeable, particularly early in therapy.
How serious is the interaction between Papaverine and Primidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel about drowsiness and avoidance of hazardous activities until the response is known. No dose change is usually needed.
What other medicines interact with Papaverine?
MediHelp also lists interactions of Papaverine with, for example, Givinostat, Bretylium, Calcium / magnesium / potassium / sodium oxybates. The full list is on the Papaverine page.
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