Drug interactions
Paromomycin + Tenofovir disoproxil
Severity: Minor
Paromomycin and Tenofovir disoproxil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tenofovir disoproxil can cause renal tubular injury, and paromomycin is an aminoglycoside with nephrotoxic potential if absorbed, which is more likely with inflamed or damaged bowel. Oral paromomycin has little systemic absorption, so the practical risk is usually small, but combined renal injury is possible in at-risk patients.
What this interaction means in plain words
Paromomycin and Tenofovir disoproxil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive nephrotoxicity from two agents with potential for renal tubular damage.
What to do
Monitor serum creatinine and phosphate in patients with renal impairment or intestinal ulceration receiving both drugs. Reassess therapy if renal function declines.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Paromomycin
- Cidofovir + Paromomycin Major
- Adefovir + Paromomycin Moderate
- Amikacin + Paromomycin Moderate
- Amphotericin b + Paromomycin Moderate
- Atracurium + Paromomycin Moderate
- Bacitracin-neomycin-polymyxin + Paromomycin Moderate
Frequently asked questions
Can I take Paromomycin with Tenofovir disoproxil?
MediHelp rates the interaction as minor. Paromomycin and Tenofovir disoproxil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tenofovir disoproxil can cause renal tubular injury, and paromomycin is an aminoglycoside with nephrotoxic potential if absorbed, which is more likely with inflamed or damaged bowel. Oral paromomycin has little systemic absorption, so the practical risk is usually small, but combined renal injury is possible in at-risk patients.
How serious is the interaction between Paromomycin and Tenofovir disoproxil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and phosphate in patients with renal impairment or intestinal ulceration receiving both drugs. Reassess therapy if renal function declines.
What other medicines interact with Paromomycin?
MediHelp also lists interactions of Paromomycin with, for example, Cidofovir, Adefovir, Amikacin. The full list is on the Paromomycin page.
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