Drug interactions
Paroxetine + Phentermine
Severity: Moderate
Paroxetine and Phentermine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phentermine is a sympathomimetic that releases norepinephrine, and serotonin syndrome has been reported with serotonergic drugs. Hypertension and tachycardia may also be added to by SSRIs.
What this interaction means in plain words
Paroxetine and Phentermine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Paroxetine belongs to Central Nervous System; Phentermine belongs to Central Nervous System.
Why it happens
Possible additive monoaminergic effects; the mechanism is not firmly established.
What to do
Monitor blood pressure, heart rate and for serotonin toxicity symptoms. Stop phentermine if serotonin syndrome is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Other interactions of Phentermine
- Isocarboxazid + Phentermine Contraindicated
- Linezolid + Phentermine Contraindicated
- Phenelzine + Phentermine Contraindicated
- Phentermine + Procarbazine Contraindicated
- Phentermine + Rasagiline Contraindicated
- Phentermine + Selegiline Contraindicated
Frequently asked questions
Can I take Paroxetine with Phentermine?
MediHelp rates the interaction as moderate. Paroxetine and Phentermine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Phentermine is a sympathomimetic that releases norepinephrine, and serotonin syndrome has been reported with serotonergic drugs. Hypertension and tachycardia may also be added to by SSRIs.
How serious is the interaction between Paroxetine and Phentermine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, heart rate and for serotonin toxicity symptoms. Stop phentermine if serotonin syndrome is suspected.
What other medicines interact with Paroxetine?
MediHelp also lists interactions of Paroxetine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Paroxetine page.
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