Drug interactions
Paroxetine + Piroxicam
Severity: Moderate
Paroxetine and Piroxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Paroxetine and piroxicam together increase the risk of bleeding, particularly upper gastrointestinal hemorrhage, compared with either drug alone.
What this interaction means in plain words
Paroxetine and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Paroxetine belongs to Central Nervous System; Piroxicam belongs to Musculoskeletal.
Why it happens
SSRI-induced depletion of platelet serotonin plus NSAID COX-1 inhibition and gastric mucosal injury.
What to do
Avoid long-term combination where possible; if needed, add gastroprotection with a proton pump inhibitor and monitor for GI bleeding. Use paracetamol as an alternative analgesic when suitable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Piroxicam
- Ketorolac intranasal + Piroxicam Contraindicated
- Ketorolac + Piroxicam Contraindicated
- Aceclofenac + Piroxicam Major
- Acemetacin + Piroxicam Major
- Acetylsalicylic acid + Piroxicam Major
- Alteplase + Piroxicam Major
Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Frequently asked questions
Can I take Paroxetine with Piroxicam?
MediHelp rates the interaction as moderate. Paroxetine and Piroxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Paroxetine and piroxicam together increase the risk of bleeding, particularly upper gastrointestinal hemorrhage, compared with either drug alone.
How serious is the interaction between Paroxetine and Piroxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid long-term combination where possible; if needed, add gastroprotection with a proton pump inhibitor and monitor for GI bleeding. Use paracetamol as an alternative analgesic when suitable.
What other medicines interact with Piroxicam?
MediHelp also lists interactions of Piroxicam with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Piroxicam page.
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