Drug interactions
Paroxetine + Selinexor
Severity: Moderate
Paroxetine and Selinexor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selinexor commonly causes dizziness, confusion and other neurological adverse effects, and paroxetine can also cause dizziness, sedation and cognitive effects. Using them together may add to these effects and raise the risk of falls and impaired function. No specific pharmacokinetic interaction is established.
What this interaction means in plain words
Paroxetine and Selinexor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Paroxetine belongs to Central Nervous System; Selinexor belongs to Oncology.
Why it happens
Additive central nervous system adverse effects; no specific pharmacokinetic mechanism is established.
What to do
Counsel patients to report dizziness or confusion and avoid driving or hazardous tasks. Reassess the need for paroxetine or adjust selinexor supportive care if neurological symptoms emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Other interactions of Selinexor
- Aldesleukin + Selinexor Moderate
- Alprazolam + Selinexor Moderate
- Amitriptyline + Selinexor Moderate
- Amobarbital + Selinexor Moderate
- Aripiprazole + Selinexor Moderate
- Asenapine + Selinexor Moderate
Frequently asked questions
Can I take Paroxetine with Selinexor?
MediHelp rates the interaction as moderate. Paroxetine and Selinexor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selinexor commonly causes dizziness, confusion and other neurological adverse effects, and paroxetine can also cause dizziness, sedation and cognitive effects. Using them together may add to these effects and raise the risk of falls and impaired function. No specific pharmacokinetic interaction is established.
How serious is the interaction between Paroxetine and Selinexor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to report dizziness or confusion and avoid driving or hazardous tasks. Reassess the need for paroxetine or adjust selinexor supportive care if neurological symptoms emerge.
What other medicines interact with Paroxetine?
MediHelp also lists interactions of Paroxetine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Paroxetine page.
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