Drug interactions
Paroxetine + Tazemetostat
Severity: Minor
Paroxetine and Tazemetostat: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is a CYP3A4 substrate, but paroxetine is not a meaningful CYP3A4 inhibitor. No clinically relevant increase in tazemetostat exposure is expected.
What this interaction means in plain words
Paroxetine and Tazemetostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Paroxetine belongs to Central Nervous System; Tazemetostat belongs to Miscellaneous.
Why it happens
Paroxetine weakly inhibits CYP3A4 at most; no established clinically relevant mechanism.
What to do
No dose adjustment needed; monitor for usual tazemetostat adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Other interactions of Tazemetostat
Frequently asked questions
Can I take Paroxetine with Tazemetostat?
MediHelp rates the interaction as minor. Paroxetine and Tazemetostat have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tazemetostat is a CYP3A4 substrate, but paroxetine is not a meaningful CYP3A4 inhibitor. No clinically relevant increase in tazemetostat exposure is expected.
How serious is the interaction between Paroxetine and Tazemetostat?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment needed; monitor for usual tazemetostat adverse effects.
What other medicines interact with Paroxetine?
MediHelp also lists interactions of Paroxetine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Paroxetine page.
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