Drug interactions
Paroxetine + Tipranavir
Severity: Moderate
Paroxetine and Tipranavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir boosted with ritonavir may alter paroxetine concentrations, and the interaction is not well characterized. Ritonavir inhibits CYP2D6 but is also reported to induce other pathways, so the net effect on paroxetine is uncertain. Higher exposure could cause more adverse effects.
What this interaction means in plain words
Paroxetine and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Paroxetine belongs to Central Nervous System; Tipranavir belongs to Anti Virals.
Why it happens
Possible inhibition of CYP2D6-mediated paroxetine metabolism by the ritonavir-boosted regimen; net effect uncertain.
What to do
Monitor for paroxetine adverse effects such as nausea, sedation and serotonergic symptoms, and titrate to clinical response. Adjust the dose or choose another SSRI if tolerability is poor.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Paroxetine
- Isocarboxazid + Paroxetine Contraindicated
- Methylene blue + Paroxetine Contraindicated
- Paroxetine + Phenelzine Contraindicated
- Paroxetine + Pimozide Contraindicated
- Paroxetine + Procarbazine Contraindicated
- Paroxetine + Selegiline Contraindicated
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Paroxetine with Tipranavir?
MediHelp rates the interaction as moderate. Paroxetine and Tipranavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tipranavir boosted with ritonavir may alter paroxetine concentrations, and the interaction is not well characterized. Ritonavir inhibits CYP2D6 but is also reported to induce other pathways, so the net effect on paroxetine is uncertain. Higher exposure could cause more adverse effects.
How serious is the interaction between Paroxetine and Tipranavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for paroxetine adverse effects such as nausea, sedation and serotonergic symptoms, and titrate to clinical response. Adjust the dose or choose another SSRI if tolerability is poor.
What other medicines interact with Paroxetine?
MediHelp also lists interactions of Paroxetine with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Paroxetine page.
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