Drug interactions
Pasireotide + Ribociclib
Severity: Major
Pasireotide and Ribociclib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can lengthen the QT interval, so together they may increase the chance of torsades de pointes. Pasireotide can also cause bradycardia, which adds to the risk.
What this interaction means in plain words
Pasireotide and Ribociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pasireotide belongs to Endocrine; Ribociclib belongs to Oncology.
Why it happens
Additive QT prolongation, with pasireotide-related bradycardia as a contributing factor.
What to do
Avoid if possible; otherwise perform baseline and follow-up ECGs, correct potassium and magnesium, and reduce or stop a drug if QTc becomes significantly prolonged.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Ribociclib
- Amiodarone + Ribociclib Contraindicated
- Cisapride + Ribociclib Contraindicated
- Dofetilide + Ribociclib Contraindicated
- Dronedarone + Ribociclib Contraindicated
- Flibanserin + Ribociclib Contraindicated
- Ibutilide + Ribociclib Contraindicated
Other interactions of Pasireotide
- Dronedarone + Pasireotide Contraindicated
- Pasireotide + Pimozide Contraindicated
- Amiodarone + Pasireotide Major
- Amisulpride + Pasireotide Major
- Amitriptyline + Pasireotide Major
- Anagrelide + Pasireotide Major
Frequently asked questions
Can I take Pasireotide with Ribociclib?
MediHelp rates the interaction as major. Pasireotide and Ribociclib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can lengthen the QT interval, so together they may increase the chance of torsades de pointes. Pasireotide can also cause bradycardia, which adds to the risk.
How serious is the interaction between Pasireotide and Ribociclib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise perform baseline and follow-up ECGs, correct potassium and magnesium, and reduce or stop a drug if QTc becomes significantly prolonged.
What other medicines interact with Ribociclib?
MediHelp also lists interactions of Ribociclib with, for example, Amiodarone, Cisapride, Dofetilide. The full list is on the Ribociclib page.
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