Drug interactions
Pasireotide + Solifenacin
Severity: Moderate
Pasireotide and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pasireotide and solifenacin can each prolong the QT interval, so combining them may raise the risk of serious ventricular arrhythmia. Pasireotide also causes bradycardia, which adds to the risk.
What this interaction means in plain words
Pasireotide and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pasireotide belongs to Endocrine; Solifenacin belongs to Genitourinary.
Why it happens
Additive QT prolongation, with pasireotide-related bradycardia increasing arrhythmia susceptibility.
What to do
Check baseline ECG and electrolytes, and correct hypokalemia and hypomagnesemia. Monitor QTc periodically during co-therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Other interactions of Pasireotide
- Dronedarone + Pasireotide Contraindicated
- Pasireotide + Pimozide Contraindicated
- Amiodarone + Pasireotide Major
- Amisulpride + Pasireotide Major
- Amitriptyline + Pasireotide Major
- Anagrelide + Pasireotide Major
Frequently asked questions
Can I take Pasireotide with Solifenacin?
MediHelp rates the interaction as moderate. Pasireotide and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pasireotide and solifenacin can each prolong the QT interval, so combining them may raise the risk of serious ventricular arrhythmia. Pasireotide also causes bradycardia, which adds to the risk.
How serious is the interaction between Pasireotide and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and electrolytes, and correct hypokalemia and hypomagnesemia. Monitor QTc periodically during co-therapy.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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