Drug interactions
Pazopanib + Pravastatin
Severity: Moderate
Pazopanib and Pravastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pazopanib inhibits OATP1B1 in vitro and may raise pravastatin exposure. Muscle toxicity could be more likely, though clinical data are limited.
What this interaction means in plain words
Pazopanib and Pravastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pazopanib belongs to Oncology; Pravastatin belongs to Cardiovascular.
Why it happens
Inhibition of OATP1B1-mediated hepatic uptake of pravastatin by pazopanib.
What to do
Monitor for muscle pain, weakness and CK elevation. Consider a lower pravastatin dose if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pravastatin
Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Frequently asked questions
Can I take Pazopanib with Pravastatin?
MediHelp rates the interaction as moderate. Pazopanib and Pravastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pazopanib inhibits OATP1B1 in vitro and may raise pravastatin exposure. Muscle toxicity could be more likely, though clinical data are limited.
How serious is the interaction between Pazopanib and Pravastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for muscle pain, weakness and CK elevation. Consider a lower pravastatin dose if symptoms occur.
What other medicines interact with Pravastatin?
MediHelp also lists interactions of Pravastatin with, for example, Cyclosporine, Cyclosporin, Gemfibrozil. The full list is on the Pravastatin page.
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