Drug interactions
Pazopanib + Rosuvastatin
Severity: Moderate
Pazopanib and Rosuvastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pazopanib inhibits OATP1B1 and BCRP in vitro, so it may raise rosuvastatin exposure. Higher levels could increase the risk of myopathy, and pazopanib itself can cause hepatotoxicity.
What this interaction means in plain words
Pazopanib and Rosuvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pazopanib belongs to Oncology; Rosuvastatin belongs to Cardiovascular.
Why it happens
Pazopanib inhibits OATP1B1 and BCRP, which reduces hepatic uptake and efflux of rosuvastatin.
What to do
Monitor for muscle pain or weakness and check creatine kinase if symptoms occur. Consider a lower rosuvastatin dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Pazopanib and Rosuvastatin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Rosuvastatin
Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Frequently asked questions
Can I take Pazopanib with Rosuvastatin?
MediHelp rates the interaction as moderate. Pazopanib and Rosuvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pazopanib inhibits OATP1B1 and BCRP in vitro, so it may raise rosuvastatin exposure. Higher levels could increase the risk of myopathy, and pazopanib itself can cause hepatotoxicity.
How serious is the interaction between Pazopanib and Rosuvastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for muscle pain or weakness and check creatine kinase if symptoms occur. Consider a lower rosuvastatin dose.
What other medicines interact with Rosuvastatin?
MediHelp also lists interactions of Rosuvastatin with, for example, Atazanavir, Cyclosporine, Cyclosporin. The full list is on the Rosuvastatin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
