Drug interactions
Pazopanib + Solifenacin
Severity: Moderate
Pazopanib and Solifenacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, so combined use may increase the risk of torsades de pointes, particularly with other risk factors. Pazopanib carries a labeled QT warning and solifenacin has dose-related QT effects.
What this interaction means in plain words
Pazopanib and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pazopanib belongs to Oncology; Solifenacin belongs to Genitourinary.
Why it happens
Additive prolongation of cardiac repolarization through effects on cardiac potassium channels.
What to do
Obtain a baseline ECG and monitor the QTc during therapy, and correct potassium and magnesium disturbances. Consider an alternative bladder antimuscarinic if the QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Solifenacin
Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Frequently asked questions
Can I take Pazopanib with Solifenacin?
MediHelp rates the interaction as moderate. Pazopanib and Solifenacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can prolong the QT interval, so combined use may increase the risk of torsades de pointes, particularly with other risk factors. Pazopanib carries a labeled QT warning and solifenacin has dose-related QT effects.
How serious is the interaction between Pazopanib and Solifenacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor the QTc during therapy, and correct potassium and magnesium disturbances. Consider an alternative bladder antimuscarinic if the QTc becomes markedly prolonged.
What other medicines interact with Solifenacin?
MediHelp also lists interactions of Solifenacin with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Solifenacin page.
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