Drug interactions
Pazopanib + Tafamidis
Severity: Minor
Pazopanib and Tafamidis: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tafamidis may raise pazopanib exposure by inhibiting BCRP, which is one of pazopanib's efflux transporters. The clinical significance is uncertain.
What this interaction means in plain words
Pazopanib and Tafamidis have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Pazopanib belongs to Oncology; Tafamidis belongs to Cardiovascular.
Why it happens
Tafamidis inhibits BCRP in vitro, reducing efflux of pazopanib.
What to do
Monitor for pazopanib toxicity, especially liver enzyme elevations and hypertension. Reduce the dose if adverse effects occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Other interactions of Tafamidis
- Apixaban + Tafamidis Moderate
- Atorvastatin + Tafamidis Moderate
- Methotrexate + Tafamidis Moderate
- Mitoxantrone + Tafamidis Moderate
- Pitavastatin + Tafamidis Moderate
- Rivaroxaban + Tafamidis Moderate
Frequently asked questions
Can I take Pazopanib with Tafamidis?
MediHelp rates the interaction as minor. Pazopanib and Tafamidis have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tafamidis may raise pazopanib exposure by inhibiting BCRP, which is one of pazopanib's efflux transporters. The clinical significance is uncertain.
How serious is the interaction between Pazopanib and Tafamidis?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for pazopanib toxicity, especially liver enzyme elevations and hypertension. Reduce the dose if adverse effects occur.
What other medicines interact with Pazopanib?
MediHelp also lists interactions of Pazopanib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pazopanib page.
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