Drug interactions
Pazopanib + Tazemetostat
Severity: Moderate
Pazopanib and Tazemetostat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tazemetostat is a weak-to-moderate CYP3A4 inducer and may lower pazopanib levels, while pazopanib, a weak CYP3A4 inhibitor, may raise tazemetostat levels. The net effect is unpredictable.
What this interaction means in plain words
Pazopanib and Tazemetostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pazopanib belongs to Oncology; Tazemetostat belongs to Miscellaneous.
Why it happens
Opposing CYP3A4 effects: tazemetostat induces and pazopanib weakly inhibits CYP3A4 metabolism.
What to do
Monitor for loss of pazopanib efficacy and for tazemetostat adverse effects. Adjust doses according to tolerability and response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Other interactions of Tazemetostat
Frequently asked questions
Can I take Pazopanib with Tazemetostat?
MediHelp rates the interaction as moderate. Pazopanib and Tazemetostat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tazemetostat is a weak-to-moderate CYP3A4 inducer and may lower pazopanib levels, while pazopanib, a weak CYP3A4 inhibitor, may raise tazemetostat levels. The net effect is unpredictable.
How serious is the interaction between Pazopanib and Tazemetostat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for loss of pazopanib efficacy and for tazemetostat adverse effects. Adjust doses according to tolerability and response.
What other medicines interact with Pazopanib?
MediHelp also lists interactions of Pazopanib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pazopanib page.
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