Drug interactions
Pazopanib + Vemurafenib
Severity: Major
Pazopanib and Vemurafenib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and vemurafenib may also affect pazopanib exposure through CYP interactions. The combination raises the risk of arrhythmia and other toxicities.
What this interaction means in plain words
Pazopanib and Vemurafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pazopanib belongs to Oncology; Vemurafenib belongs to Oncology.
Why it happens
Additive QT prolongation, with possible pharmacokinetic interaction via CYP3A4 and P-gp.
What to do
Avoid combination where possible. If used together, monitor ECG, electrolytes and liver function.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Other interactions of Vemurafenib
Frequently asked questions
Can I take Pazopanib with Vemurafenib?
MediHelp rates the interaction as major. Pazopanib and Vemurafenib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs can prolong the QT interval, and vemurafenib may also affect pazopanib exposure through CYP interactions. The combination raises the risk of arrhythmia and other toxicities.
How serious is the interaction between Pazopanib and Vemurafenib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combination where possible. If used together, monitor ECG, electrolytes and liver function.
What other medicines interact with Pazopanib?
MediHelp also lists interactions of Pazopanib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pazopanib page.
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