Drug interactions
Pazopanib + Vorinostat
Severity: Major
Pazopanib and Vorinostat: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs have been associated with QT prolongation, so combined use may increase the risk of torsades de pointes. Risk is higher with electrolyte disturbances or structural heart disease.
What this interaction means in plain words
Pazopanib and Vorinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pazopanib belongs to Oncology; Vorinostat belongs to Oncology.
Why it happens
Additive effects on cardiac repolarization.
What to do
Obtain baseline ECG and electrolytes and monitor periodically. Correct hypokalemia and hypomagnesemia, and avoid the combination in patients with long QT.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Pazopanib
- Adagrasib + Pazopanib Major
- Amiodarone + Pazopanib Major
- Amisulpride + Pazopanib Major
- Amobarbital + Pazopanib Major
- Anagrelide + Pazopanib Major
- Apalutamide + Pazopanib Major
Other interactions of Vorinostat
- Thioridazine + Vorinostat Contraindicated
- Amiodarone + Vorinostat Major
- Amisulpride + Vorinostat Major
- Anagrelide + Vorinostat Major
- Asenapine + Vorinostat Major
- Chlorpromazine + Vorinostat Major
Frequently asked questions
Can I take Pazopanib with Vorinostat?
MediHelp rates the interaction as major. Pazopanib and Vorinostat can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both drugs have been associated with QT prolongation, so combined use may increase the risk of torsades de pointes. Risk is higher with electrolyte disturbances or structural heart disease.
How serious is the interaction between Pazopanib and Vorinostat?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain baseline ECG and electrolytes and monitor periodically. Correct hypokalemia and hypomagnesemia, and avoid the combination in patients with long QT.
What other medicines interact with Pazopanib?
MediHelp also lists interactions of Pazopanib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pazopanib page.
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