Drug interactions
Pegaspargase + Siponimod
Severity: Moderate
Pegaspargase and Siponimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pegaspargase is used with chemotherapy for leukemia and is associated with infections and hepatotoxicity, and siponimod lowers lymphocytes. Combined use may add to infection risk, and both can affect liver tests.
What this interaction means in plain words
Pegaspargase and Siponimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pegaspargase belongs to Oncology; Siponimod belongs to Central Nervous System.
Why it happens
Additive immune effects from asparaginase-related protein synthesis depletion and S1P-mediated lymphocyte sequestration.
What to do
Monitor infection signs and liver tests, and consider interrupting siponimod during intensive leukemia chemotherapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Siponimod
- Cladribine + Siponimod Contraindicated
- Fingolimod + Siponimod Contraindicated
- Fluconazole + Siponimod Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Siponimod Contraindicated
- Ponesimod + Siponimod Contraindicated
- Siponimod + Thioridazine Contraindicated
Other interactions of Pegaspargase
- Etodolac + Pegaspargase Major
- Ketorolac + Pegaspargase Major
- Mefenamic acid + Pegaspargase Major
- Acetylsalicylic acid + Pegaspargase Moderate
- Argatroban + Pegaspargase Moderate
- Celecoxib + Pegaspargase Moderate
Frequently asked questions
Can I take Pegaspargase with Siponimod?
MediHelp rates the interaction as moderate. Pegaspargase and Siponimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pegaspargase is used with chemotherapy for leukemia and is associated with infections and hepatotoxicity, and siponimod lowers lymphocytes. Combined use may add to infection risk, and both can affect liver tests.
How serious is the interaction between Pegaspargase and Siponimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor infection signs and liver tests, and consider interrupting siponimod during intensive leukemia chemotherapy.
What other medicines interact with Siponimod?
MediHelp also lists interactions of Siponimod with, for example, Cladribine, Fingolimod, Fluconazole. The full list is on the Siponimod page.
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