Drug interactions
Pemigatinib + Verapamil
Severity: Major
Pemigatinib and Verapamil: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pemigatinib is cleared mainly by CYP3A4, and verapamil is a moderate inhibitor of this enzyme. Taking them together can increase pemigatinib exposure and the risk of toxicities such as hyperphosphatemia and ocular effects.
What this interaction means in plain words
Pemigatinib and Verapamil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pemigatinib belongs to Oncology; Verapamil belongs to Cardiovascular.
Why it happens
Verapamil inhibits CYP3A4 and reduces the metabolism of pemigatinib.
What to do
Prefer an alternative to verapamil. If it must be used, reduce the pemigatinib dose as set out in its labeling and monitor for adverse effects, restoring the dose about three half-lives after verapamil is stopped.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Pemigatinib
Frequently asked questions
Can I take Pemigatinib with Verapamil?
MediHelp rates the interaction as major. Pemigatinib and Verapamil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pemigatinib is cleared mainly by CYP3A4, and verapamil is a moderate inhibitor of this enzyme. Taking them together can increase pemigatinib exposure and the risk of toxicities such as hyperphosphatemia and ocular effects.
How serious is the interaction between Pemigatinib and Verapamil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer an alternative to verapamil. If it must be used, reduce the pemigatinib dose as set out in its labeling and monitor for adverse effects, restoring the dose about three half-lives after verapamil is stopped.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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