Drug interactions
Penbutolol + Sevoflurane
Severity: Moderate
Penbutolol and Sevoflurane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Beta-blockers and volatile anesthetics both reduce myocardial contractility and blood pressure. Together they can cause more hypotension and bradycardia, although continuing beta-blockers perioperatively is generally preferred to abrupt withdrawal.
What this interaction means in plain words
Penbutolol and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive negative inotropic, chronotropic and vasodilatory effects.
What to do
Continue the beta-blocker perioperatively and monitor blood pressure, heart rate and ECG. Treat bradycardia or hypotension promptly with an anticholinergic, fluids or vasopressors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sevoflurane
Frequently asked questions
Can I take Penbutolol with Sevoflurane?
MediHelp rates the interaction as moderate. Penbutolol and Sevoflurane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Beta-blockers and volatile anesthetics both reduce myocardial contractility and blood pressure. Together they can cause more hypotension and bradycardia, although continuing beta-blockers perioperatively is generally preferred to abrupt withdrawal.
How serious is the interaction between Penbutolol and Sevoflurane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Continue the beta-blocker perioperatively and monitor blood pressure, heart rate and ECG. Treat bradycardia or hypotension promptly with an anticholinergic, fluids or vasopressors.
What other medicines interact with Sevoflurane?
MediHelp also lists interactions of Sevoflurane with, for example, Amiodarone, Amisulpride, Arsenic trioxide. The full list is on the Sevoflurane page.
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