Drug interactions
Penbutolol + Tiotropium-olodaterol
Severity: Major
Penbutolol and Tiotropium-olodaterol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Penbutolol is a non-selective beta-blocker that blocks beta2 receptors and opposes the bronchodilating effect of olodaterol. It may also cause severe bronchospasm in patients with COPD or asthma.
What this interaction means in plain words
Penbutolol and Tiotropium-olodaterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Pharmacodynamic antagonism at beta2-adrenergic receptors.
What to do
Avoid non-selective beta-blockers in patients with obstructive airway disease. If a beta-blocker is essential, use a cardioselective agent at low dose and monitor respiratory function.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Penbutolol and Tiotropium-olodaterol, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Tiotropium-olodaterol
Frequently asked questions
Can I take Penbutolol with Tiotropium-olodaterol?
MediHelp rates the interaction as major. Penbutolol and Tiotropium-olodaterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Penbutolol is a non-selective beta-blocker that blocks beta2 receptors and opposes the bronchodilating effect of olodaterol. It may also cause severe bronchospasm in patients with COPD or asthma.
How serious is the interaction between Penbutolol and Tiotropium-olodaterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid non-selective beta-blockers in patients with obstructive airway disease. If a beta-blocker is essential, use a cardioselective agent at low dose and monitor respiratory function.
What other medicines interact with Tiotropium-olodaterol?
MediHelp also lists interactions of Tiotropium-olodaterol with, for example, Amisulpride, Arformoterol, Arsenic trioxide. The full list is on the Tiotropium-olodaterol page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
