Drug interactions
Penicillin g + Salsalate
Severity: Minor
Penicillin g and Salsalate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salsalate is hydrolyzed to salicylic acid, which may compete with penicillin G for renal secretion and protein binding, modestly increasing penicillin exposure. The effect is usually small.
What this interaction means in plain words
Penicillin g and Salsalate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Competition for plasma protein binding and renal tubular organic anion secretion by salicylate.
What to do
No routine adjustment is needed; monitor for penicillin adverse effects with high doses or renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Penicillin g
- Amifampridine + Penicillin g Moderate
- Amiloride + Penicillin g Moderate
- Bcg vaccine live + Penicillin g Moderate
- Cholera vaccine + Penicillin g Moderate
- Colestipol + Penicillin g Moderate
- Deflazacort + Penicillin g Moderate
Frequently asked questions
Can I take Penicillin g with Salsalate?
MediHelp rates the interaction as minor. Penicillin g and Salsalate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Salsalate is hydrolyzed to salicylic acid, which may compete with penicillin G for renal secretion and protein binding, modestly increasing penicillin exposure. The effect is usually small.
How serious is the interaction between Penicillin g and Salsalate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor for penicillin adverse effects with high doses or renal impairment.
What other medicines interact with Penicillin g?
MediHelp also lists interactions of Penicillin g with, for example, Amifampridine, Amiloride, Bcg vaccine live. The full list is on the Penicillin g page.
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