Drug interactions
Penicillin g + Typhoid vaccine live
Severity: Moderate
Penicillin g and Typhoid vaccine live: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral live typhoid vaccine (Ty21a) contains viable Salmonella Typhi that must colonize the gut to induce immunity. Antibacterial agents active against the strain can reduce its viability and weaken the immune response.
What this interaction means in plain words
Penicillin g and Typhoid vaccine live can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antibacterial activity reduces survival and replication of the live attenuated Salmonella vaccine strain.
What to do
Delay the live typhoid vaccine until the antibiotic course has finished, or use the inactivated injectable vaccine if vaccination cannot wait.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Penicillin g and Typhoid vaccine live, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Penicillin g
- Amifampridine + Penicillin g Moderate
- Amiloride + Penicillin g Moderate
- Bcg vaccine live + Penicillin g Moderate
- Cholera vaccine + Penicillin g Moderate
- Colestipol + Penicillin g Moderate
- Deflazacort + Penicillin g Moderate
Frequently asked questions
Can I take Penicillin g with Typhoid vaccine live?
MediHelp rates the interaction as moderate. Penicillin g and Typhoid vaccine live can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral live typhoid vaccine (Ty21a) contains viable Salmonella Typhi that must colonize the gut to induce immunity. Antibacterial agents active against the strain can reduce its viability and weaken the immune response.
How serious is the interaction between Penicillin g and Typhoid vaccine live?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Delay the live typhoid vaccine until the antibiotic course has finished, or use the inactivated injectable vaccine if vaccination cannot wait.
What other medicines interact with Penicillin g?
MediHelp also lists interactions of Penicillin g with, for example, Amifampridine, Amiloride, Bcg vaccine live. The full list is on the Penicillin g page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
