Drug interactions
Pentamidine + Pimozide
Severity: Contraindicated
Pentamidine and Pimozide: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pentamidine, especially intravenously, can prolong the QT interval and cause torsades de pointes. Added to pimozide, the arrhythmia risk increases.
What this interaction means in plain words
Pentamidine and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Pentamidine belongs to Anti Parasitic; Pimozide belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Avoid. Use an alternative anti-infective such as atovaquone where appropriate, or stop pimozide with ECG monitoring if pentamidine is essential.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Other interactions of Pentamidine
- Clomipramine + Pentamidine Contraindicated
- Desipramine + Pentamidine Contraindicated
- Dronedarone + Pentamidine Contraindicated
- Moxifloxacin + Pentamidine Contraindicated
- Nortriptyline + Pentamidine Contraindicated
- Pentamidine + Thioridazine Contraindicated
Frequently asked questions
Can I take Pentamidine with Pimozide?
MediHelp rates the interaction as contraindicated. Pentamidine and Pimozide are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Pentamidine, especially intravenously, can prolong the QT interval and cause torsades de pointes. Added to pimozide, the arrhythmia risk increases.
How serious is the interaction between Pentamidine and Pimozide?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid. Use an alternative anti-infective such as atovaquone where appropriate, or stop pimozide with ECG monitoring if pentamidine is essential.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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