Drug interactions
Dronedarone + Pentamidine
Severity: Contraindicated
Dronedarone and Pentamidine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pentamidine, particularly when given intravenously, can prolong the QT interval and cause torsades de pointes. Combined with dronedarone the arrhythmia risk is substantially increased.
What this interaction means in plain words
Dronedarone and Pentamidine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dronedarone belongs to Cardiovascular; Pentamidine belongs to Anti Parasitic.
Why it happens
Additive QT interval prolongation through cardiac repolarization effects.
What to do
Avoid the combination; use an alternative anti-infective or hold dronedarone, with ECG and electrolyte monitoring if unavoidable.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Pentamidine
- Clomipramine + Pentamidine Contraindicated
- Desipramine + Pentamidine Contraindicated
- Moxifloxacin + Pentamidine Contraindicated
- Nortriptyline + Pentamidine Contraindicated
- Pentamidine + Pimozide Contraindicated
- Pentamidine + Thioridazine Contraindicated
Frequently asked questions
Can I take Dronedarone with Pentamidine?
MediHelp rates the interaction as contraindicated. Dronedarone and Pentamidine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Pentamidine, particularly when given intravenously, can prolong the QT interval and cause torsades de pointes. Combined with dronedarone the arrhythmia risk is substantially increased.
How serious is the interaction between Dronedarone and Pentamidine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; use an alternative anti-infective or hold dronedarone, with ECG and electrolyte monitoring if unavoidable.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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