Drug interactions
Moxifloxacin + Pentamidine
Severity: Contraindicated
Moxifloxacin and Pentamidine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can prolong the QT interval, and pentamidine has been associated with torsades de pointes. Together they increase the chance of life-threatening ventricular arrhythmia.
What this interaction means in plain words
Moxifloxacin and Pentamidine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Moxifloxacin belongs to Anti Bacterial; Pentamidine belongs to Anti Parasitic.
Why it happens
Additive QT prolongation through effects on cardiac repolarization currents.
What to do
Avoid the combination and select a non-QT-prolonging antibiotic. If pentamidine is essential, obtain baseline and follow-up ECGs and correct potassium and magnesium.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Moxifloxacin
- Amiodarone + Moxifloxacin Contraindicated
- Arsenic trioxide + Moxifloxacin Contraindicated
- Disopyramide + Moxifloxacin Contraindicated
- Dofetilide + Moxifloxacin Contraindicated
- Dronedarone + Moxifloxacin Contraindicated
- Droperidol + Moxifloxacin Contraindicated
Other interactions of Pentamidine
- Clomipramine + Pentamidine Contraindicated
- Desipramine + Pentamidine Contraindicated
- Dronedarone + Pentamidine Contraindicated
- Nortriptyline + Pentamidine Contraindicated
- Pentamidine + Pimozide Contraindicated
- Pentamidine + Thioridazine Contraindicated
Frequently asked questions
Can I take Moxifloxacin with Pentamidine?
MediHelp rates the interaction as contraindicated. Moxifloxacin and Pentamidine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both agents can prolong the QT interval, and pentamidine has been associated with torsades de pointes. Together they increase the chance of life-threatening ventricular arrhythmia.
How serious is the interaction between Moxifloxacin and Pentamidine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and select a non-QT-prolonging antibiotic. If pentamidine is essential, obtain baseline and follow-up ECGs and correct potassium and magnesium.
What other medicines interact with Moxifloxacin?
MediHelp also lists interactions of Moxifloxacin with, for example, Amiodarone, Arsenic trioxide, Disopyramide. The full list is on the Moxifloxacin page.
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