Drug interactions
Nortriptyline + Pentamidine
Severity: Contraindicated
Nortriptyline and Pentamidine: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can prolong the QT interval, and pentamidine has been associated with torsades de pointes. The combination increases arrhythmia risk.
What this interaction means in plain words
Nortriptyline and Pentamidine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Nortriptyline belongs to Central Nervous System; Pentamidine belongs to Anti Parasitic.
Why it happens
Additive QT prolongation.
What to do
Avoid the combination. If pentamidine is essential, consider withholding nortriptyline and monitor ECG and electrolytes.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Nortriptyline
- Disopyramide + Nortriptyline Contraindicated
- Dofetilide + Nortriptyline Contraindicated
- Dronedarone + Nortriptyline Contraindicated
- Ibutilide + Nortriptyline Contraindicated
- Isocarboxazid + Nortriptyline Contraindicated
- Methylene blue + Nortriptyline Contraindicated
Other interactions of Pentamidine
- Clomipramine + Pentamidine Contraindicated
- Desipramine + Pentamidine Contraindicated
- Dronedarone + Pentamidine Contraindicated
- Moxifloxacin + Pentamidine Contraindicated
- Pentamidine + Pimozide Contraindicated
- Pentamidine + Thioridazine Contraindicated
Frequently asked questions
Can I take Nortriptyline with Pentamidine?
MediHelp rates the interaction as contraindicated. Nortriptyline and Pentamidine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Both drugs can prolong the QT interval, and pentamidine has been associated with torsades de pointes. The combination increases arrhythmia risk.
How serious is the interaction between Nortriptyline and Pentamidine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. If pentamidine is essential, consider withholding nortriptyline and monitor ECG and electrolytes.
What other medicines interact with Nortriptyline?
MediHelp also lists interactions of Nortriptyline with, for example, Disopyramide, Dofetilide, Dronedarone. The full list is on the Nortriptyline page.
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