Drug interactions
Pentobarbital + Temsirolimus
Severity: Moderate
Pentobarbital and Temsirolimus: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Barbiturates induce CYP3A4 and may lower temsirolimus and sirolimus exposure, potentially reducing efficacy. The effect is more pronounced with prolonged use.
What this interaction means in plain words
Pentobarbital and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Induction of CYP3A4 by pentobarbital increases temsirolimus metabolism.
What to do
Use a non-inducing alternative when possible; otherwise monitor for reduced response and consider the labeled temsirolimus dose increase for sustained use of strong inducers.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Temsirolimus
- Bcg vaccine live + Temsirolimus Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Temsirolimus Contraindicated
- Measles mumps and rubella vaccine live + Temsirolimus Contraindicated
- Measles mumps rubella and varicella vaccine live + Temsirolimus Contraindicated
- Measles vaccine + Temsirolimus Contraindicated
- Rotavirus oral vaccine live + Temsirolimus Contraindicated
Frequently asked questions
Can I take Pentobarbital with Temsirolimus?
MediHelp rates the interaction as moderate. Pentobarbital and Temsirolimus can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Barbiturates induce CYP3A4 and may lower temsirolimus and sirolimus exposure, potentially reducing efficacy. The effect is more pronounced with prolonged use.
How serious is the interaction between Pentobarbital and Temsirolimus?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-inducing alternative when possible; otherwise monitor for reduced response and consider the labeled temsirolimus dose increase for sustained use of strong inducers.
What other medicines interact with Temsirolimus?
MediHelp also lists interactions of Temsirolimus with, for example, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal, Measles mumps and rubella vaccine live. The full list is on the Temsirolimus page.
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