Drug interactions
Pentobarbital + Trimipramine
Severity: Moderate
Pentobarbital and Trimipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pentobarbital and trimipramine both depress the CNS, so the combination can cause excessive sedation and impaired psychomotor function. Barbiturates also induce hepatic enzymes and may lower tricyclic levels, while tricyclics lower the seizure threshold.
What this interaction means in plain words
Pentobarbital and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression plus barbiturate-mediated induction of hepatic metabolism of trimipramine.
What to do
Monitor sedation and respiratory status, and review antidepressant response. Adjust the trimipramine dose if efficacy is lost.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Pentobarbital with Trimipramine?
MediHelp rates the interaction as moderate. Pentobarbital and Trimipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pentobarbital and trimipramine both depress the CNS, so the combination can cause excessive sedation and impaired psychomotor function. Barbiturates also induce hepatic enzymes and may lower tricyclic levels, while tricyclics lower the seizure threshold.
How serious is the interaction between Pentobarbital and Trimipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation and respiratory status, and review antidepressant response. Adjust the trimipramine dose if efficacy is lost.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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