Drug interactions
Pentobarbital + Vortioxetine
Severity: Moderate
Pentobarbital and Vortioxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pentobarbital induces hepatic CYP enzymes and may lower vortioxetine exposure, possibly reducing antidepressant effect. Additive sedation may also occur.
What this interaction means in plain words
Pentobarbital and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Barbiturate-mediated induction of CYP enzymes increases vortioxetine clearance, with additive CNS depression.
What to do
Monitor antidepressant response and consider increasing the vortioxetine dose if prolonged inducer use is needed, not exceeding three times the original dose. Reduce back when the inducer is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Frequently asked questions
Can I take Pentobarbital with Vortioxetine?
MediHelp rates the interaction as moderate. Pentobarbital and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pentobarbital induces hepatic CYP enzymes and may lower vortioxetine exposure, possibly reducing antidepressant effect. Additive sedation may also occur.
How serious is the interaction between Pentobarbital and Vortioxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor antidepressant response and consider increasing the vortioxetine dose if prolonged inducer use is needed, not exceeding three times the original dose. Reduce back when the inducer is stopped.
What other medicines interact with Vortioxetine?
MediHelp also lists interactions of Vortioxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Vortioxetine page.
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