Drug interactions
Pentosan polysulfate + Vortioxetine
Severity: Moderate
Pentosan polysulfate and Vortioxetine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pentosan polysulfate is a weak anticoagulant, and vortioxetine impairs platelet function. Together they may increase the risk of bleeding.
What this interaction means in plain words
Pentosan polysulfate and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hemostatic impairment: heparin-like anticoagulant activity plus reduced platelet serotonin uptake.
What to do
Monitor for bleeding and bruising, and check the blood count if symptoms occur. Reassess the need for both drugs in patients with other bleeding risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vortioxetine
- Isocarboxazid + Vortioxetine Contraindicated
- Linezolid + Vortioxetine Contraindicated
- Methylene blue + Vortioxetine Contraindicated
- Phenelzine + Vortioxetine Contraindicated
- Rasagiline + Vortioxetine Contraindicated
- Selegiline transdermal + Vortioxetine Contraindicated
Frequently asked questions
Can I take Pentosan polysulfate with Vortioxetine?
MediHelp rates the interaction as moderate. Pentosan polysulfate and Vortioxetine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pentosan polysulfate is a weak anticoagulant, and vortioxetine impairs platelet function. Together they may increase the risk of bleeding.
How serious is the interaction between Pentosan polysulfate and Vortioxetine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and bruising, and check the blood count if symptoms occur. Reassess the need for both drugs in patients with other bleeding risk factors.
What other medicines interact with Vortioxetine?
MediHelp also lists interactions of Vortioxetine with, for example, Isocarboxazid, Linezolid, Methylene blue. The full list is on the Vortioxetine page.
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