Drug interactions
Perindopril + Pregabalin
Severity: Moderate
Perindopril and Pregabalin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both ACE inhibitors and pregabalin have been associated with angioedema of the face, lips, tongue and throat. Using them together may raise the risk, and airway swelling can be life-threatening.
What this interaction means in plain words
Perindopril and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Perindopril belongs to Cardiovascular; Pregabalin belongs to Central Nervous System.
Why it happens
Both drugs can independently cause angioedema; ACE inhibitors act via bradykinin accumulation, and the pregabalin mechanism is not established.
What to do
Counsel patients to stop both drugs and seek emergency care if swelling of the face, lips, tongue or throat occurs. Review the need for the combination in patients with prior angioedema.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perindopril
- Aliskiren + Perindopril Contraindicated
- Perindopril + Protein a column Contraindicated
- Perindopril + Sacubitril / valsartan Contraindicated
- Perindopril + Sacubitril-valsartan Contraindicated
- Amifostine + Perindopril Major
- Amiloride + Perindopril Major
Other interactions of Pregabalin
Frequently asked questions
Can I take Perindopril with Pregabalin?
MediHelp rates the interaction as moderate. Perindopril and Pregabalin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both ACE inhibitors and pregabalin have been associated with angioedema of the face, lips, tongue and throat. Using them together may raise the risk, and airway swelling can be life-threatening.
How serious is the interaction between Perindopril and Pregabalin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Counsel patients to stop both drugs and seek emergency care if swelling of the face, lips, tongue or throat occurs. Review the need for the combination in patients with prior angioedema.
What other medicines interact with Perindopril?
MediHelp also lists interactions of Perindopril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Perindopril page.
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