Drug interactions
Perphenazine + Phenelzine
Severity: Moderate
Perphenazine and Phenelzine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perphenazine with phenelzine can cause additive hypotension, sedation and anticholinergic effects. MAO inhibitors may also prolong or intensify the extrapyramidal effects of phenothiazines, and serotonin toxicity or neuroleptic malignant syndrome are rare possibilities.
What this interaction means in plain words
Perphenazine and Phenelzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Perphenazine belongs to Central Nervous System; Phenelzine belongs to Central Nervous System.
Why it happens
Additive pharmacodynamic effects of MAO inhibition with potent D2 blockade and alpha-adrenergic and antimuscarinic actions.
What to do
Use the lowest effective perphenazine dose and monitor blood pressure, extrapyramidal symptoms and mental status. Stop the antipsychotic and treat urgently if fever, rigidity or autonomic instability develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Perphenazine with Phenelzine?
MediHelp rates the interaction as moderate. Perphenazine and Phenelzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Perphenazine with phenelzine can cause additive hypotension, sedation and anticholinergic effects. MAO inhibitors may also prolong or intensify the extrapyramidal effects of phenothiazines, and serotonin toxicity or neuroleptic malignant syndrome are rare possibilities.
How serious is the interaction between Perphenazine and Phenelzine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective perphenazine dose and monitor blood pressure, extrapyramidal symptoms and mental status. Stop the antipsychotic and treat urgently if fever, rigidity or autonomic instability develops.
What other medicines interact with Phenelzine?
MediHelp also lists interactions of Phenelzine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Phenelzine page.
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