Drug interactions
Perphenazine + Primidone
Severity: Moderate
Perphenazine and Primidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Primidone is metabolized to phenobarbital and depresses the CNS, adding to perphenazine's sedation. Enzyme induction can lower perphenazine levels, and perphenazine may lower the seizure threshold, reducing anticonvulsant control.
What this interaction means in plain words
Perphenazine and Primidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Perphenazine belongs to Central Nervous System; Primidone belongs to Central Nervous System.
Why it happens
Additive CNS depression and hepatic enzyme induction by primidone and its metabolite phenobarbital.
What to do
Monitor sedation, seizure frequency and psychiatric response. Adjust perphenazine or primidone doses as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Other interactions of Primidone
- Lorlatinib + Primidone Contraindicated
- Lurasidone + Primidone Contraindicated
- Primidone + Ranolazine Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Voriconazole Contraindicated
- Abiraterone + Primidone Major
Frequently asked questions
Can I take Perphenazine with Primidone?
MediHelp rates the interaction as moderate. Perphenazine and Primidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Primidone is metabolized to phenobarbital and depresses the CNS, adding to perphenazine's sedation. Enzyme induction can lower perphenazine levels, and perphenazine may lower the seizure threshold, reducing anticonvulsant control.
How serious is the interaction between Perphenazine and Primidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation, seizure frequency and psychiatric response. Adjust perphenazine or primidone doses as needed.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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