Drug interactions
Perphenazine + Pseudoephedrine
Severity: Moderate
Perphenazine and Pseudoephedrine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sympathomimetics can increase heart rate and provoke arrhythmias, while phenothiazines may prolong the QT interval and have alpha-blocking effects. Together they may raise arrhythmic risk, and phenothiazines may also blunt the pressor response to some sympathomimetics.
What this interaction means in plain words
Perphenazine and Pseudoephedrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Perphenazine belongs to Central Nervous System; Pseudoephedrine belongs to Respiratory.
Why it happens
Combined pharmacodynamic effects of adrenergic cardiac stimulation and phenothiazine-related QT prolongation and alpha-blockade.
What to do
Prefer non-sympathomimetic decongestant alternatives in patients with cardiac risk factors; monitor heart rate, blood pressure and rhythm if combined.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Pseudoephedrine
- Isocarboxazid + Pseudoephedrine Contraindicated
- Phenelzine + Pseudoephedrine Contraindicated
- Pseudoephedrine + Rasagiline Contraindicated
- Pseudoephedrine + Selegiline Contraindicated
- Pseudoephedrine + Selegiline transdermal Contraindicated
- Pseudoephedrine + Tranylcypromine Contraindicated
Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Perphenazine with Pseudoephedrine?
MediHelp rates the interaction as moderate. Perphenazine and Pseudoephedrine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sympathomimetics can increase heart rate and provoke arrhythmias, while phenothiazines may prolong the QT interval and have alpha-blocking effects. Together they may raise arrhythmic risk, and phenothiazines may also blunt the pressor response to some sympathomimetics.
How serious is the interaction between Perphenazine and Pseudoephedrine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer non-sympathomimetic decongestant alternatives in patients with cardiac risk factors; monitor heart rate, blood pressure and rhythm if combined.
What other medicines interact with Pseudoephedrine?
MediHelp also lists interactions of Pseudoephedrine with, for example, Isocarboxazid, Phenelzine, Rasagiline. The full list is on the Pseudoephedrine page.
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