Drug interactions
Perphenazine + Ramipril
Severity: Minor
Perphenazine and Ramipril: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perphenazine can cause orthostatic hypotension, and combined use with ramipril may add to blood pressure lowering. The effect is usually modest.
What this interaction means in plain words
Perphenazine and Ramipril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Perphenazine belongs to Central Nervous System; Ramipril belongs to Cardiovascular.
Why it happens
Additive hypotensive effects from alpha-adrenergic blockade and ACE inhibition.
What to do
Monitor blood pressure and orthostatic symptoms when starting or adjusting either drug.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ramipril
- Aliskiren + Ramipril Contraindicated
- Protein a column + Ramipril Contraindicated
- Ramipril + Sacubitril / valsartan Contraindicated
- Ramipril + Sacubitril-valsartan Contraindicated
- Amifostine + Ramipril Major
- Amiloride + Ramipril Major
Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Perphenazine with Ramipril?
MediHelp rates the interaction as minor. Perphenazine and Ramipril have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Perphenazine can cause orthostatic hypotension, and combined use with ramipril may add to blood pressure lowering. The effect is usually modest.
How serious is the interaction between Perphenazine and Ramipril?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and orthostatic symptoms when starting or adjusting either drug.
What other medicines interact with Ramipril?
MediHelp also lists interactions of Ramipril with, for example, Aliskiren, Protein a column, Sacubitril / valsartan. The full list is on the Ramipril page.
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