Drug interactions
Perphenazine + Safinamide
Severity: Major
Perphenazine and Safinamide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perphenazine blocks dopamine receptors and counteracts the dopaminergic benefit of safinamide in Parkinson disease. Motor symptoms may worsen, and extrapyramidal effects from the antipsychotic may add to them.
What this interaction means in plain words
Perphenazine and Safinamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Perphenazine belongs to Central Nervous System; Safinamide belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism via D2 receptor blockade.
What to do
Avoid typical antipsychotics such as perphenazine in Parkinson disease. If antipsychotic treatment is necessary, use quetiapine or clozapine.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Other interactions of Safinamide
- Amitriptyline + Safinamide Contraindicated
- Amoxapine + Safinamide Contraindicated
- Amphetamine polistirex + Safinamide Contraindicated
- Clomipramine + Safinamide Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Desipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Perphenazine with Safinamide?
MediHelp rates the interaction as major. Perphenazine and Safinamide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Perphenazine blocks dopamine receptors and counteracts the dopaminergic benefit of safinamide in Parkinson disease. Motor symptoms may worsen, and extrapyramidal effects from the antipsychotic may add to them.
How serious is the interaction between Perphenazine and Safinamide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid typical antipsychotics such as perphenazine in Parkinson disease. If antipsychotic treatment is necessary, use quetiapine or clozapine.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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