Drug interactions
Perphenazine + Scopolamine
Severity: Moderate
Perphenazine and Scopolamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perphenazine has modest anticholinergic activity and causes sedation, so scopolamine can add to dry mouth, constipation, urinary retention, blurred vision and confusion. Antimuscarinic agents are sometimes given on purpose to treat antipsychotic-induced extrapyramidal symptoms, but excessive anticholinergic load can still develop.
What this interaction means in plain words
Perphenazine and Scopolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Perphenazine belongs to Central Nervous System; Scopolamine belongs to Respiratory.
Why it happens
Additive muscarinic receptor blockade and CNS depression.
What to do
Monitor for anticholinergic toxicity, sedation and cognitive change, especially in older patients. Reduce the dose of one agent if these effects are troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Scopolamine
Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Perphenazine with Scopolamine?
MediHelp rates the interaction as moderate. Perphenazine and Scopolamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Perphenazine has modest anticholinergic activity and causes sedation, so scopolamine can add to dry mouth, constipation, urinary retention, blurred vision and confusion. Antimuscarinic agents are sometimes given on purpose to treat antipsychotic-induced extrapyramidal symptoms, but excessive anticholinergic load can still develop.
How serious is the interaction between Perphenazine and Scopolamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic toxicity, sedation and cognitive change, especially in older patients. Reduce the dose of one agent if these effects are troublesome.
What other medicines interact with Scopolamine?
MediHelp also lists interactions of Scopolamine with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Scopolamine page.
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