Drug interactions
Perphenazine + Selegiline
Severity: Moderate
Perphenazine and Selegiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Selegiline, an MAO-B inhibitor, opposes the effect of dopamine blockers in parkinsonism, and perphenazine may blunt its therapeutic benefit. Rare serotonergic toxicity or neuroleptic malignant syndrome has been theorized.
What this interaction means in plain words
Perphenazine and Selegiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Perphenazine belongs to Central Nervous System; Selegiline belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism between dopamine agonism and D2 receptor blockade, with possible serotonergic effects.
What to do
Avoid perphenazine in Parkinson disease where possible and choose quetiapine or clozapine if an antipsychotic is needed. Monitor for worsening motor symptoms, hyperthermia and rigidity.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Frequently asked questions
Can I take Perphenazine with Selegiline?
MediHelp rates the interaction as moderate. Perphenazine and Selegiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Selegiline, an MAO-B inhibitor, opposes the effect of dopamine blockers in parkinsonism, and perphenazine may blunt its therapeutic benefit. Rare serotonergic toxicity or neuroleptic malignant syndrome has been theorized.
How serious is the interaction between Perphenazine and Selegiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid perphenazine in Parkinson disease where possible and choose quetiapine or clozapine if an antipsychotic is needed. Monitor for worsening motor symptoms, hyperthermia and rigidity.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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