Drug interactions
Perphenazine + Siponimod
Severity: Moderate
Perphenazine and Siponimod: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Siponimod can cause bradycardia and may affect conduction, and perphenazine can prolong the QT interval. Together they may raise the risk of arrhythmia.
What this interaction means in plain words
Perphenazine and Siponimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Perphenazine belongs to Central Nervous System; Siponimod belongs to Central Nervous System.
Why it happens
Additive effects on cardiac conduction and repolarization.
What to do
Obtain an ECG before starting siponimod and consider cardiology input given the QT-prolonging drug. Monitor heart rate and QTc during first-dose observation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Other interactions of Siponimod
- Cladribine + Siponimod Contraindicated
- Fingolimod + Siponimod Contraindicated
- Fluconazole + Siponimod Contraindicated
- Influenza virus vaccine quadrivalent intranasal + Siponimod Contraindicated
- Ponesimod + Siponimod Contraindicated
- Siponimod + Thioridazine Contraindicated
Frequently asked questions
Can I take Perphenazine with Siponimod?
MediHelp rates the interaction as moderate. Perphenazine and Siponimod can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Siponimod can cause bradycardia and may affect conduction, and perphenazine can prolong the QT interval. Together they may raise the risk of arrhythmia.
How serious is the interaction between Perphenazine and Siponimod?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain an ECG before starting siponimod and consider cardiology input given the QT-prolonging drug. Monitor heart rate and QTc during first-dose observation.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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