Drug interactions
Perphenazine + Sorafenib
Severity: Moderate
Perphenazine and Sorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sorafenib can prolong the QT interval, as can perphenazine, so combined use may increase the risk of torsades de pointes. Risk rises with electrolyte disturbances.
What this interaction means in plain words
Perphenazine and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Perphenazine belongs to Central Nervous System; Sorafenib belongs to Oncology.
Why it happens
Additive prolongation of cardiac repolarization.
What to do
Check baseline ECG and correct potassium, magnesium and calcium. Repeat ECG during therapy and consider alternatives if QTc becomes markedly prolonged.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Other interactions of Sorafenib
Frequently asked questions
Can I take Perphenazine with Sorafenib?
MediHelp rates the interaction as moderate. Perphenazine and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sorafenib can prolong the QT interval, as can perphenazine, so combined use may increase the risk of torsades de pointes. Risk rises with electrolyte disturbances.
How serious is the interaction between Perphenazine and Sorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check baseline ECG and correct potassium, magnesium and calcium. Repeat ECG during therapy and consider alternatives if QTc becomes markedly prolonged.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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