Drug interactions
Perphenazine + Telavancin
Severity: Moderate
Perphenazine and Telavancin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Perphenazine and telavancin can each prolong the QTc interval. Combined use may increase the risk of torsades de pointes, particularly with electrolyte abnormalities.
What this interaction means in plain words
Perphenazine and Telavancin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Perphenazine belongs to Central Nervous System; Telavancin belongs to Anti Bacterial.
Why it happens
Additive prolongation of ventricular repolarization.
What to do
Obtain a baseline ECG and monitor QTc and electrolytes during co-therapy. Use an alternative antibiotic if the patient has other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Telavancin
- Telavancin + Thioridazine Contraindicated
- Adagrasib + Telavancin Major
- Amiodarone + Telavancin Major
- Amisulpride + Telavancin Major
- Anagrelide + Telavancin Major
- Arsenic trioxide + Telavancin Major
Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Frequently asked questions
Can I take Perphenazine with Telavancin?
MediHelp rates the interaction as moderate. Perphenazine and Telavancin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Perphenazine and telavancin can each prolong the QTc interval. Combined use may increase the risk of torsades de pointes, particularly with electrolyte abnormalities.
How serious is the interaction between Perphenazine and Telavancin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc and electrolytes during co-therapy. Use an alternative antibiotic if the patient has other QT risk factors.
What other medicines interact with Telavancin?
MediHelp also lists interactions of Telavancin with, for example, Thioridazine, Adagrasib, Amiodarone. The full list is on the Telavancin page.
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