Drug interactions
Perphenazine + Tretinoin
Severity: Minor
Perphenazine and Tretinoin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenothiazines can cause photosensitivity, and tretinoin can also increase sensitivity to sunlight, so additive phototoxic reactions are possible. This is mainly a concern with systemic tretinoin. The effect is generally manageable.
What this interaction means in plain words
Perphenazine and Tretinoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Perphenazine belongs to Central Nervous System; Tretinoin belongs to Dermatology.
Why it happens
Additive photosensitizing effects.
What to do
Advise strict sun protection, protective clothing and sunscreen. Review for skin reactions during therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Other interactions of Tretinoin
- Doxycycline + Tretinoin Major
- Minocycline + Tretinoin Major
- Omadacycline + Tretinoin Major
- Palovarotene + Tretinoin Major
- Sarecycline + Tretinoin Major
- Tetracycline + Tretinoin Major
Frequently asked questions
Can I take Perphenazine with Tretinoin?
MediHelp rates the interaction as minor. Perphenazine and Tretinoin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Phenothiazines can cause photosensitivity, and tretinoin can also increase sensitivity to sunlight, so additive phototoxic reactions are possible. This is mainly a concern with systemic tretinoin. The effect is generally manageable.
How serious is the interaction between Perphenazine and Tretinoin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise strict sun protection, protective clothing and sunscreen. Review for skin reactions during therapy.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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