Drug interactions
Perphenazine + Zuranolone
Severity: Moderate
Perphenazine and Zuranolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zuranolone causes somnolence and impaired driving ability, and perphenazine adds sedation. Together they may increase psychomotor impairment and CNS depression.
What this interaction means in plain words
Perphenazine and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Perphenazine belongs to Central Nervous System; Zuranolone belongs to Central Nervous System.
Why it happens
Additive CNS depression through GABA-A modulation and antihistaminic and antidopaminergic sedation.
What to do
Monitor for excessive sedation and consider reducing the zuranolone dose if impairment occurs. Advise patients not to drive or operate machinery for at least 12 hours after each dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Other interactions of Zuranolone
- Alprazolam + Zuranolone Major
- Amobarbital + Zuranolone Major
- Apalutamide + Zuranolone Major
- Asenapine + Zuranolone Major
- Brexpiprazole + Zuranolone Major
- Butorphanol + Zuranolone Major
Frequently asked questions
Can I take Perphenazine with Zuranolone?
MediHelp rates the interaction as moderate. Perphenazine and Zuranolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Zuranolone causes somnolence and impaired driving ability, and perphenazine adds sedation. Together they may increase psychomotor impairment and CNS depression.
How serious is the interaction between Perphenazine and Zuranolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and consider reducing the zuranolone dose if impairment occurs. Advise patients not to drive or operate machinery for at least 12 hours after each dose.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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