Drug interactions
Pexidartinib + Quinidine
Severity: Major
Pexidartinib and Quinidine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pexidartinib induces CYP3A4 and may substantially lower quinidine concentrations, risking therapeutic failure. Both drugs can also affect the liver, and pexidartinib carries a boxed warning for serious hepatotoxicity.
What this interaction means in plain words
Pexidartinib and Quinidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pexidartinib belongs to Oncology; Quinidine belongs to Anti Parasitic.
Why it happens
Pexidartinib induces CYP3A4, increasing quinidine clearance, and the combination adds to hepatotoxic burden.
What to do
Avoid the combination. If unavoidable, monitor quinidine levels, ECG and liver tests closely and adjust the quinidine dose.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Pexidartinib
Frequently asked questions
Can I take Pexidartinib with Quinidine?
MediHelp rates the interaction as major. Pexidartinib and Quinidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pexidartinib induces CYP3A4 and may substantially lower quinidine concentrations, risking therapeutic failure. Both drugs can also affect the liver, and pexidartinib carries a boxed warning for serious hepatotoxicity.
How serious is the interaction between Pexidartinib and Quinidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination. If unavoidable, monitor quinidine levels, ECG and liver tests closely and adjust the quinidine dose.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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