Drug interactions
Pexidartinib + Secobarbital
Severity: Major
Pexidartinib and Secobarbital: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pexidartinib is a CYP3A4 substrate, and barbiturate induction may reduce its exposure. This could lessen its effect on tenosynovial giant cell tumor.
What this interaction means in plain words
Pexidartinib and Secobarbital can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pexidartinib belongs to Oncology; Secobarbital belongs to Central Nervous System.
Why it happens
CYP3A4 induction lowers pexidartinib plasma concentrations.
What to do
Avoid the combination and use a non-inducing alternative. Monitor tumor response if it must be used.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Other interactions of Pexidartinib
Frequently asked questions
Can I take Pexidartinib with Secobarbital?
MediHelp rates the interaction as major. Pexidartinib and Secobarbital can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pexidartinib is a CYP3A4 substrate, and barbiturate induction may reduce its exposure. This could lessen its effect on tenosynovial giant cell tumor.
How serious is the interaction between Pexidartinib and Secobarbital?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-inducing alternative. Monitor tumor response if it must be used.
What other medicines interact with Secobarbital?
MediHelp also lists interactions of Secobarbital with, for example, Calcium / magnesium / potassium / sodium oxybates, Doravirine, Elbasvir / grazoprevir. The full list is on the Secobarbital page.
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