Drug interactions
Pexidartinib + Sertraline
Severity: Minor
Pexidartinib and Sertraline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pexidartinib is metabolised by CYP3A4, and inhibitors raise exposure, which may increase the risk of hepatotoxicity. Sertraline is a weak CYP3A4 inhibitor, so the effect is probably small.
What this interaction means in plain words
Pexidartinib and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Pexidartinib belongs to Oncology; Sertraline belongs to Central Nervous System.
Why it happens
Weak CYP3A4 inhibition by sertraline reducing pexidartinib clearance.
What to do
No dose change is required; monitor liver tests as required by pexidartinib labeling. Avoid stronger CYP3A4 inhibitors.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Other interactions of Pexidartinib
Frequently asked questions
Can I take Pexidartinib with Sertraline?
MediHelp rates the interaction as minor. Pexidartinib and Sertraline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Pexidartinib is metabolised by CYP3A4, and inhibitors raise exposure, which may increase the risk of hepatotoxicity. Sertraline is a weak CYP3A4 inhibitor, so the effect is probably small.
How serious is the interaction between Pexidartinib and Sertraline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is required; monitor liver tests as required by pexidartinib labeling. Avoid stronger CYP3A4 inhibitors.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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