Drug interactions
Pexidartinib + Simvastatin
Severity: Moderate
Pexidartinib and Simvastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pexidartinib carries a boxed warning for serious and potentially fatal liver injury, and simvastatin can also raise liver enzymes. Combining them may add to the hepatic burden. Pexidartinib may also lower simvastatin exposure through weak CYP3A induction.
What this interaction means in plain words
Pexidartinib and Simvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Pexidartinib belongs to Oncology; Simvastatin belongs to Cardiovascular.
Why it happens
Additive hepatotoxic potential, with possible weak CYP3A4 induction by pexidartinib lowering simvastatin exposure.
What to do
Monitor liver enzymes closely at baseline and regularly during combined therapy, and stop one agent if transaminases or bilirubin rise significantly. Check lipid response, as simvastatin efficacy may be reduced.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Pexidartinib and Simvastatin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Simvastatin
- Atazanavir + Simvastatin Contraindicated
- Clarithromycin + Simvastatin Contraindicated
- Cobicistat + Simvastatin Contraindicated
- Cyclosporine + Simvastatin Contraindicated
- Cyclosporin + Simvastatin Contraindicated
- Danazol + Simvastatin Contraindicated
Other interactions of Pexidartinib
Frequently asked questions
Can I take Pexidartinib with Simvastatin?
MediHelp rates the interaction as moderate. Pexidartinib and Simvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pexidartinib carries a boxed warning for serious and potentially fatal liver injury, and simvastatin can also raise liver enzymes. Combining them may add to the hepatic burden. Pexidartinib may also lower simvastatin exposure through weak CYP3A induction.
How serious is the interaction between Pexidartinib and Simvastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver enzymes closely at baseline and regularly during combined therapy, and stop one agent if transaminases or bilirubin rise significantly. Check lipid response, as simvastatin efficacy may be reduced.
What other medicines interact with Simvastatin?
MediHelp also lists interactions of Simvastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Simvastatin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
