Drug interactions
Pexidartinib + Sulindac
Severity: Major
Pexidartinib and Sulindac: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pexidartinib carries a boxed warning for serious and potentially fatal liver injury. Sulindac is among the NSAIDs with a recognized, though uncommon, risk of hepatotoxicity, so combining them may add to liver risk.
What this interaction means in plain words
Pexidartinib and Sulindac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Pexidartinib belongs to Oncology; Sulindac belongs to Musculoskeletal.
Why it happens
Additive hepatotoxic potential from two drugs that can independently cause liver injury.
What to do
Avoid co-use where possible and choose a non-hepatotoxic analgesic. If used together, monitor liver enzymes and bilirubin closely and stop therapy at signs of liver injury.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Other interactions of Pexidartinib
Frequently asked questions
Can I take Pexidartinib with Sulindac?
MediHelp rates the interaction as major. Pexidartinib and Sulindac can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pexidartinib carries a boxed warning for serious and potentially fatal liver injury. Sulindac is among the NSAIDs with a recognized, though uncommon, risk of hepatotoxicity, so combining them may add to liver risk.
How serious is the interaction between Pexidartinib and Sulindac?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid co-use where possible and choose a non-hepatotoxic analgesic. If used together, monitor liver enzymes and bilirubin closely and stop therapy at signs of liver injury.
What other medicines interact with Sulindac?
MediHelp also lists interactions of Sulindac with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Sulindac page.
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