Drug interactions
Phendimetrazine + Trimipramine
Severity: Major
Phendimetrazine and Trimipramine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phendimetrazine is a sympathomimetic anorectic, and combining it with a tricyclic may cause unpredictable pressor effects, hypertension, tachycardia and arrhythmia. Tricyclics may also reduce the indirect effects of amphetamine-like drugs.
What this interaction means in plain words
Phendimetrazine and Trimipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Tricyclic blockade of norepinephrine reuptake alters the response to sympathomimetics, with additive adrenergic stimulation.
What to do
Avoid the combination where possible. If used, monitor blood pressure and heart rhythm.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Trimipramine
- Disopyramide + Trimipramine Contraindicated
- Dofetilide + Trimipramine Contraindicated
- Ibutilide + Trimipramine Contraindicated
- Isocarboxazid + Trimipramine Contraindicated
- Pentamidine + Trimipramine Contraindicated
- Phenelzine + Trimipramine Contraindicated
Frequently asked questions
Can I take Phendimetrazine with Trimipramine?
MediHelp rates the interaction as major. Phendimetrazine and Trimipramine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Phendimetrazine is a sympathomimetic anorectic, and combining it with a tricyclic may cause unpredictable pressor effects, hypertension, tachycardia and arrhythmia. Tricyclics may also reduce the indirect effects of amphetamine-like drugs.
How serious is the interaction between Phendimetrazine and Trimipramine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible. If used, monitor blood pressure and heart rhythm.
What other medicines interact with Trimipramine?
MediHelp also lists interactions of Trimipramine with, for example, Disopyramide, Dofetilide, Ibutilide. The full list is on the Trimipramine page.
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