Drug interactions
Phenelzine + Zolmitriptan
Severity: Contraindicated
Phenelzine and Zolmitriptan: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Phenelzine's MAO-A inhibition reduces zolmitriptan clearance, increasing exposure to it and its active metabolite. Combined serotonergic effects raise the risk of serotonin syndrome. Use is contraindicated.
What this interaction means in plain words
Phenelzine and Zolmitriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Phenelzine belongs to Central Nervous System; Zolmitriptan belongs to Central Nervous System.
Why it happens
MAO inhibition slows zolmitriptan metabolism, and both agents enhance serotonergic signaling.
What to do
Avoid co-use and allow 2 weeks after stopping phenelzine. Use a non-triptan acute migraine drug.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Other interactions of Zolmitriptan
- Almotriptan + Zolmitriptan Contraindicated
- Dihydroergotamine intranasal + Zolmitriptan Contraindicated
- Dihydroergotamine + Zolmitriptan Contraindicated
- Eletriptan + Zolmitriptan Contraindicated
- Ergoloid mesylates + Zolmitriptan Contraindicated
- Ergotamine + Zolmitriptan Contraindicated
Frequently asked questions
Can I take Phenelzine with Zolmitriptan?
MediHelp rates the interaction as contraindicated. Phenelzine and Zolmitriptan are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Phenelzine's MAO-A inhibition reduces zolmitriptan clearance, increasing exposure to it and its active metabolite. Combined serotonergic effects raise the risk of serotonin syndrome. Use is contraindicated.
How serious is the interaction between Phenelzine and Zolmitriptan?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid co-use and allow 2 weeks after stopping phenelzine. Use a non-triptan acute migraine drug.
What other medicines interact with Phenelzine?
MediHelp also lists interactions of Phenelzine with, for example, 5-HTP, Amitriptyline, Amoxapine. The full list is on the Phenelzine page.
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